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  3. Medical: Pharmaceuticals

Target engagement

German translation: Zielmolekülbindung

07:39 Jul 6, 2023
English to German translations [PRO]
Medical - Medical: Pharmaceuticals / Clinical trial
English term or phrase: Target engagement
I hope someone can help me with this please. I'm doing a back translation of a clinical trial related text which has been translated from English into German (and now back into English by me). The title of the trial says "to Evaluate Safety, Tolerability, Pharmacokinetics and ***Target Engagement *** of Single Intravenous and Subcutaneous Doses".
This has been translated into German as
"zur Beurteilung der Sicherheit, der Verträglichkeit, der Pharmakokinetik und des Zielkontakts..."
I want to check "Zielkontakt" for Target Engagement, because it seems a bit iffy. "Target engagement (TE) in drug discovery is generally defined as the interaction of ligands with their target biomolecules." if that helps. Maybe it is fine but I would be very grateful if someone could confirm whether or not it is okay, and it isn't then what it should be…
Charles Stanford
Czech Republic
Local time: 08:10
German translation:Zielmolekülbindung
Explanation:
Ich glaube, es vermittelt die Vorstellung von der Interaktion eines Arzneimittels mit seinem Zielmolekül im Körper.
Selected response from:

Sakshi Garg
India
Local time: 11:40
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3Zielmolekülbindung
Sakshi Garg
3Target Engagement
Zea_Mays


Discussion entries: 3





  

Answers


47 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
target engagement
Zielmolekülbindung


Explanation:
Ich glaube, es vermittelt die Vorstellung von der Interaktion eines Arzneimittels mit seinem Zielmolekül im Körper.

Sakshi Garg
India
Local time: 11:40
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 4
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2 days 6 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
target engagement
Target Engagement


Explanation:
Bedeutet so viel wie "inwieweit die gewünschte Wirkung erzielt wird".

Da die "Targets" unterschiedlich sind, wird glaube ich häufig der englische Begriff verwendet zusammen mit einer für den jeweiligen Kontext spezifischen Erläuterung.

Bsp: "Im Wesentlichen geht es dabei in erster Linie um die Sicherheit, gefolgt von einem “Biomarker” dafür, wie die Gehirnzellen auf die Behandlung reagieren, und einem Maß dafür, ob das Medikament biologisch so wirkt, wie es soll - dies wird als “Target Engagement” bezeichnet. "
https://de.hdbuzz.net/327

In manchen Fällen geht es auch um "Interaktion".

"Das Nanobret TE nutzt den Biolumineszenz-Resonanzenergietransfer, eine Technologie, die eine Echtzeit-Untersuchung von Protein-Wirkstoff-Interaktionen (Target Engagement) in lebenden Zellen mit einem einfach aufgebauten Laborprotokoll ermöglicht."
https://www.laborpraxis.vogel.de/wirkstoffaffinitaet-in-lebe...


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Note added at 5 Tage (2023-07-11 09:42:01 GMT) Post-grading
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Hi Charles, "Interaktion" (mit einem Zielmolekül) only applies where this is actually meant. That's why often the English term is kept as it has multiple meanings.

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Note added at 5 Tage (2023-07-11 09:57:21 GMT) Post-grading
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Getting the points is not my concern. If you award points to the wrong answer by choosing it this may mislead other users when looking for how to translate this term. But hopefully they will also read the discussion.

Zea_Mays
Italy
Local time: 08:10
Native speaker of: Native in GermanGerman, Native in ItalianItalian
Notes to answerer
Asker: Thanks very much again Zea. I apologise for not giving you the points (wish I could split them). I did find quite a lot of evidence that TE is just left in EN in DE texts so I think you are right

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