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chimeric antigen receptor (CAR) T-cell therapy

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00:54 Aug 18, 2021
English to Ukrainian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: chimeric antigen receptor (CAR) T-cell therapy
Definition from American Cancer Association:
Chimeric antigen receptor (CAR) T-cell therapy is a promising new way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapies are sometimes talked about as a type of gene or cell therapy, or immune effect cell therapy.

Example sentence(s):
  • Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, which has prompted the search for alternative antigen targets. Research Square
  • Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. PubMed
  • In the past 5 years, knowledge of immunology in thoracic cancers has greatly improved. The results observed with immunotherapy are encouraging. For example, in patients with stage 4 non–small cell lung cancer, 5-year survival was previously 2%. That survival rate has now increased to approximately 20% with the use of checkpoint blockade immunotherapy. Similarly, early data from our trial combining chimeric antigen receptor (CAR) T-cell therapy and checkpoint blockade in mesothelioma were promising. Hematology & Oncology
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
4скорочено CAR-T-клітинна терапія
Vladyslav Golovaty


  

Translations offered


6 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
скорочено CAR-T-клітинна терапія


Definition from https://uamt.com.ua/:
«CAR-T терапія» - це метод лікування в імунотерапії, що базується на використанні власних клітин пацієнта для руйнування ракових клітин.

Example sentence(s):
  • ЗАСТОСУВАННЯ В ОНКОЛОГІЇ ГЕНЕТИЧНО МОДИФІКОВАНИХ Т-ЛІМФОЦИТІВ, ЩО ЕКСПРЕСУЮТЬ ХИМЕРНІ АНТИГЕННІ РЕЦЕПТОРИ В огляді узагальнено клінічний досвід застосування CAR T-клітинної терапії у хворих із неходжкінською лімфомою, хронічним лімфоцитарним лейкозом, гострим лімфобластним лейкозом і солідними пухлинами. Описано проблеми на шляху CAR T-клітинної терапії солідних пухлин та токсичні ефекти імунотерапії. - medradiologia.org.ua  
  • Клітинна імунотерапія (CAR-T). Найбільш перспективний вид імунотерапії, ... Цей метод використовується одночасно з променевою терапією або хіміотерапією. - www.clinic-target.com  
  • повна назва: Т-клітинна терапія химерними антигенними рецепторами (CAR) Останніми роками застосування модифікованих Т-клітин химерного рецептора антигену (Chimeric antigen receptor — CAR) стало потужним засобом лікування рецидивуючих та рефрактерних гематологічних злоякісних новоутворень - www.umj.com.ua  
Vladyslav Golovaty
Ukraine
Local time: 20:39
Native speaker of: Native in EnglishEnglish, Native in RussianRussian
PRO pts in category: 206
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