inflammasome

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00:55 Oct 27, 2021
English to Japanese translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Chemistry; Chem Sci/Eng, Medical: Pharmaceuticals
English term or phrase: inflammasome
Definition from Oxford English Dictionary:
A complex of proteins in the cytoplasm that regulates the activation of enzymes involved in immune and inflammatory responses to pathogens.

Example sentence(s):
  • Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases, including autoinflammatory disorders, cardiometabolic diseases, cancer and neurodegenerative diseases. Nature Portfolio
  • The adaptor protein ASC must become linearly ubiquitinated and phosphorylated for inflammasome assembly to occur. After priming, canonical NLRP3 inflammasome activation requires a second, distinct signal to activate NLRP3 and lead to the formation of the NLRP3 inflammasome complex. National Center for Biotechnology Info
  • Potassium ion efflux (a common inflammasome activator) is an essential factor for the assembly and up-regulation of NLRP3 complexes induced by the agonist adenosine triphosphate (ATP). Molecular Cancer
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5 +1インフラマソーム
Kayoko Kimura


  

Translations offered


8 hrs   confidence: Answerer confidence 5/5 peer agreement (net): +1
インフラマソーム


Definition from 脳科学辞典:
インフラマソームとは、炎症反応を惹起するための細胞内タンパク質複合体である。

Example sentence(s):
  • "Danger signals" の番人インフラマソーム - MBL Immunology News  
  • 炎症応答において重要なインフラマソームの構成タンパク質であるASCの活性化の機構 - ライフサイエンス新着論文レ�  
  • インフラマソームではタンパク分解酵素の一種であるカスパーゼ-1が活性化され、活性型カスパーゼ-1がインターロイキン-1などの炎症性サイトカインの成熟化・分泌を誘導することで炎症が起こります。 - 京都大学  
Kayoko Kimura
United States
Local time: 02:41
Native speaker of: Native in JapaneseJapanese
PRO pts in category: 111

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