gene deletion

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00:54 Mar 3, 2021

English to Danish translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals, Genetics

English term or phrase: gene deletion

Definition from National Cancer :
The loss of all or a part of a gene. There may also be a change in the RNA and protein made from that gene. Certain gene deletions are found in cancer and in other genetic diseases and abnormalities.

Example sentence(s):

Gene deletions can also be applied in many different plant and human pathogenic fungi in order to decrease their pathogenicity and/or virulence for different applications. ScienceDirect
It is notable that targeted gene deletions generated via CRISPR/Cas9 and two guide RNAs resulted in the formation of correct junctions at high efficiency. Future Science
In the genomics era there is great demand for fast, simple high-throughput methods for gene deletion to study the roles of the large numbers of genes that are being identified. PubMed

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Summary of translations provided

gendeletion

Mai-Britt Mosbech

Discussion entries: 1

Translations offered

451 days confidence:

gendeletion

Definition from own experience or research:
En gendeletion er når en del af den kodende DNA-sekvens for et gen slettes og medfører at genet ikke længere kan udtrykkes i en aktiv form.

Example sentence(s):

Vi har identificeret og bekræftet en ~525 KB deletion på kromosom 23, der forårsager dødfødsler hos kvæg. Fra studiet kan fremhæves at: 1. genotypedeletion vil kunne rekapitulere populationers genetiske struktur, 2. der findes nogle højt differentierede gendeletioner og intergendeletioner blandt populationerne, 3. deletioner i vigtige gener kunne kun observeres hos heterozygoter, mens der i mindre vigtige gener kunne ses levende homozygote individer, 4. naturlige gen-knockouts bliver berigede, hvad angår immunrelaterede og lugtreceptoriske gener, 5. deletioner bliver i høj grad beriget hvad angår helbreds- og fertilitetsrelaterede QTL, mens de i høj grad er tømte hvad angår produktionsegenskaber, 6. kendskabet til deletionsbrudpunkter fremmer forståelsen af de mekanismer, der forårsager dannelsen af deletioner. - MBG, Aarhus Universitet
I genetik er en deletion (også kaldet gendeletion , mangel eller deletionsmutation ) (tegn: Δ ) en mutation (en genetisk aberration), hvor en del af et kromosom eller en sekvens af DNA udelades under DNA-replikation. Et hvilket som helst antal nukleotider kan deleteres, fra en enkelt base til et helt stykke kromosom. - wblog/wiki
Ved en deletion eller tabsmutation er et stykke af et kromosom forsvundet. Et kromosom med genrækkefølgen abcde kan fx ændres til abde, hvis kromosomstykket med genet c er væk. Deletioner er oftest homozygotisk letale; de medfører i dobbelt dosis døden hos individer med dobbelt kromosomsæt (dvs. diploide organismer som fx mennesket). - Lex.dk/Den Store Danske

Mai-Britt Mosbech
Sweden
Local time: 06:13
Native speaker of: Danish

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