Jun 28, 2009 07:10
14 yrs ago
Japanese term

責任変異因子

Japanese to English Science Biology (-tech,-chem,micro-) Mast Cell Line (NCL-2) Derived from NC Mouse Bone Marrow
責任変異因子

Context:
NCL-2における自己増殖獲得における責任変異因子としては受容体より下流の細胞内情報伝達系に存在することが示唆された。

Proposed translations

5 hrs
Selected

mutation responsible for

I would translate the sentence as,

Mutation responsible for the acquisition of self-replication in NCL-2....

Alternatively, you may use "causative mutation"
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4 KudoZ points awarded for this answer. Comment: "I picked you because you answered first. "Responsible" seemed strange to me because I thought people and not things are responsible for things. I think "factor" should be included in the translation."
6 hrs

mutation factor

責任変異 - mutation
因子 - factor

http://ci.nii.ac.jp/naid/10017000842

SNPは数がきわめて多いので,疾患の責任変異である可能性が高い.SNPは公開データベースに格納されている.日本人DNAを用いて公開データベース内の525個のSNPsを調べたところ,27%にあたる 143個しか確認されなかった.日本では遺伝子領域を再シークエンスし,SNPを同定するプロジェクトが行われ,多数のSNPsが見出されている
http://ci.nii.ac.jp/search?q=責任変異&x=&y=&title=&author=&affil...

paper used an adaptive mutation factor to decrease the .... as the mutation factor for clone selection of increasing antibody. This factor is adaptive with ...
doi.ieeecomputersociety.org/10.1109/ISCID.2008.213

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8 hrs

responsible mutation factor

= a factor which is responsible for any mutation
・変異 Mutation
http://ejje.weblio.jp/content/変異
・生殖細胞系列変異 Germ-Line Mutation

Gain-of-function mutations of platelet-derived growth factor
... - [ このページを訳す ]... Japan) or mouse monoclonal
antibody against human CD34 (NCL-END; Novocastra Laboratories,
Newcastle upon Tyne, ... The expression vector with each
mutation was transfected into 293T human embryonic kidney cell
line by the calcium phosphate method.[12] .... (C) KIT mutation
at codon 816-Asp to Val observed in some human mast cell
tumors is shown. .... Imatinib mesylate does not appear to have
a good therapeutic effect on GISTs with the TK II domain
mutation of PDGFR α. ...
linkinghub.elsevier.com/retrieve/pii/S0016508503010461

・増殖 Growth
・身体サイズ Body Size +
・細胞増殖過程 Cell Growth Process
http://ejje.weblio.jp/content/増殖

http://www.sciencedirect.com/science?_ob=ArticleListURL&_met...
&_urlVersion=0&_userid=10&md5=bb7c19c466b21a72d69824974f1238aa


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Note added at 9 hrs (2009-06-28 16:10:10 GMT)
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Immunohistochemical KIT (CD117) Expression in Thymic Epithelial ...Two monoclonal antibodies, anti-KIT (Dako; Glostrup, Denmark) and anti-CD5 (NCL-CD5–4C5; Novocastra; ... KIT expression has also been reported in a wide variety of human solid tumors, such as mast cell tumors, germ cell tumors ... the activation of a mutation in the c-kit gene is thought to be the most important factor in the pathogenesis of .... Turner, AM, Zsebo, KM, Martin, F, et al Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors. ...
www.chestjournal.org/content/128/1/140.full
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