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Kryptonite is a fictional substance from the Superman mythos, originating in the Superman radio show series. The material, usually shown as having been created from the remains of Superman's native planet of Krypton, generally has detrimental effects on Superman. The name "kryptonite" covers a variety of forms of the substance, but usually refers to the most common "green" form.

The word "kryptonite" can be used in speech as a synonym for "weakness".

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