liz askew Aug 17, 2021:

Metformin alleviates hydrogen peroxide–induced inflammation and ...https://cdnsciencepub.com › doi › abs › cjpp-2020-0373
En vue d'étudier le mode d'action sous-jacent des effets neuroprotecteurs de la ... épinière, ce qui favorisait ***la libération de cytokines proinflammatoires en aval*** ...

liz askew Aug 17, 2021:

Model shows active mediators of the complement cascade during inflammation in airway asthma. Further, it highlights activation of inflammatory cells (Basophils, PMNs and Macrophages) through complement receptor binding and downstream release of inflammatory mediators. As shown, all these mediators contribute in tissue damage and remodeling. APL-1 and APL-2, are derivatives of Compstatin, bind to and inhibit complement activation at the C3 level, thus blocking all major effector pathways of complement activation. (Both APL-1 and APL-2 are under clinical trials).

liz askew Aug 17, 2021:

finding only:

Complement mediators: key regulators of airway tissue ...https://translational-medicine.biomedcentral.com › articles
by MA Khan · 2015 · Cited by 28 — Asthma is a chronic inflammatory disease of the airways distinguished ... receptor binding and ****downstream release of inflammatory mediators***.