Jan 8, 2018 13:19
6 yrs ago
1 viewer *
English term
Russian Federation
10+ years of experience in Pharma
Native in: Russian (Variant: Standard-Russia)
Works in: English to Russian, Russian to English
in key players in homologous recombination
English to Russian
Medical
Medical: Pharmaceuticals
Background
One of the hallmarks and driving forces of cancer is genetic instability.
Specifically in familial cancers, susceptibility to breast cancer development due to mutations in BRCA1 and BRCA2 tumor suppressor genes, or in key players in homologous recombination (HR), have been associated with an increased risk of developing breast or ovarian cancer.
It is in these patient populations that inhibitors of poly (ADP-ribose) polymerase (PARP) have gained recent attention.
PARP family members PARP1 and PARP2 play important roles in DNA replication, transcriptional regulation, and DNA damage repair.
One of the hallmarks and driving forces of cancer is genetic instability.
Specifically in familial cancers, susceptibility to breast cancer development due to mutations in BRCA1 and BRCA2 tumor suppressor genes, or in key players in homologous recombination (HR), have been associated with an increased risk of developing breast or ovarian cancer.
It is in these patient populations that inhibitors of poly (ADP-ribose) polymerase (PARP) have gained recent attention.
PARP family members PARP1 and PARP2 play important roles in DNA replication, transcriptional regulation, and DNA damage repair.
Proposed translations
(Russian)
| 3 +1 | в генах, играющих ключевую роль в гомологической рекомбинации |
Evgeni Kushch
|
Proposed translations
+1
26 mins
Evgeni Kushch
Ukraine
Ukraine
Native in Russian
Specializes in field
Ukraine
MD with 12+ years in medical translation
Native in: Russian (Variant: Standard-Russia) 
, Ukrainian (Variant: Standard-Ukraine)
Works in: English to Russian, English to Ukrainian, Russian to English, and 3 more.
Related KudoZ points
:
1743
Selected
в генах, играющих ключевую роль в гомологической рекомбинации
или "в ключевых генах, участвующих в гомологической рекомбинации"
Я так полагаю, что имеются в виду основные гены, опосредующие гомологические рекомбинации, то есть за счет кодируемых ими белков.
Или "в ключевых генах, продукты которых участвуют в гомологической рекомбинации"
"в генах, продукты которых играют ключевую роль в гомологической рекомбинации"
Я так полагаю, что имеются в виду основные гены, опосредующие гомологические рекомбинации, то есть за счет кодируемых ими белков.
Или "в ключевых генах, продукты которых участвуют в гомологической рекомбинации"
"в генах, продукты которых играют ключевую роль в гомологической рекомбинации"
4 KudoZ points awarded for this answer.
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