English to Russian Medical Mathematics & Statistics cohort studies of drug-associated risk

Researchers from McGill University and Lady Davis Institute for Medical Research studied insurance data for 356 gabapentinoid users with epilepsy, 9,411 with neuropathic pain, and 3,737 with other chronic pain.

The gabapentinoid users were matched 1:1 to nonusers on COPD duration, indication for gabapentinoids, age, sex, calendar year, and time-conditional propensity score. The authors found that compared with nonuse, gabapentinoid use was associated with an increased risk for severe COPD exacerbation among users taking these drugs for epilepsy, neuropathic pain, and chronic pain, and peak increase in risk for severe COPD exacerbation occurred after approximately six months of continuous use.