Glossary entry

English term or phrase:

domain swap targeting vector

Russian translation:

направленный вектор для осуществления обмена доменами/перестановки доменов

    The asker opted for community grading. The question was closed on 2020-10-22 12:56:38 based on peer agreement (or, if there were too few peer comments, asker preference.)
Oct 19, 2020 09:28
3 yrs ago
10 viewers *
English term

domain swap targeting vector

English to Russian Medical Biology (-tech,-chem,micro-) gene engineering
Guide RNAs were designed to regions within exon 7 of (name of the gene) that were unique to the wild type gene and not present in the domain swap targeting vector
Change log

Oct 19, 2020 10:23: Natalia Novichenko changed "Restriction (Pairs)" from "none" to "working" , "Restriction Fields" from "none" to "specialty"

Oct 19, 2020 20:18: interprivate changed "Level" from "Non-PRO" to "PRO"

Votes to reclassify question as PRO/non-PRO:

PRO (3): DTSM, Igor Andreev, interprivate

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Proposed translations

2 hrs
Selected

направленный вектор для осуществления обмена доменами/перестановки доменов

см. схему процесса domain swap, правда с использованием ПЦР, но суть процесса не меняется, здесь https://www.researchgate.net/publication/38042895_A_simple_f...

Описание похожего вектора можно найти в статье:
https://www.researchgate.net/publication/264642609_Use_of_th...

Упоминание перестановки доменов/обмена доменами можно найти здесь:
Другой способ создания белков с новой специфичностью — обмен доменами
между разными группами белков можно проследить на примере эндонуклеазы
F-TflW.
http://static.freereferats.ru/_avtoreferats/01002978449.pdf

Как инструмент белковой инженерии, обмен доменами является относительно новым, и его возможности только начинают реализовываться.
https://rus.legatechnics.com/small-molecule-induced-domain-s...
Последняя ссылка, правда, вызывает некоторые сомнения в полной адекватности перевода
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4 KudoZ points awarded for this answer. Comment: "Спасибо, Игорь, за обстоятельный ответ"
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