Currently, the drug may be administered to a child just before feeding, although the conditions and time of administration and the composition of a meal given with thyroxine should be stable to achieve a similar absorption and determine the due dose.

Obecnie dopuszcza się podawanie leku dziecku także krótko przed karmieniem, ale warunki i czas podania leku oraz skład pokarmu podawanego z tyroksyną powinny być stałe, aby uzyskać podobny stopień wchłaniania i ustalić wysokość należnej dawki.

https://journals.viamedica.pl/endokrynologia_polska/article/...

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Note added at 40 mins (2019-03-19 13:23:39 GMT)
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If a dose of TENOLAM is missed within 12 hours of the time it is usually taken, the individual should
take the medicine as soon as possible and resume the normal dosing schedule with the next due dose.

https://extranet.who.int/prequal/sites/default/files/HA525Pa...

Look at administration record on prescription card to ensure/confirm that the due dose
has not already been given by other members of staff

https://www.tewv.nhs.uk/content/uploads/2018/09/Controlled-D...

Może to wpływać na odległe wyniki terapii, zgodnie z potwierdzonym faktem, że odstępstwa od należnej dawki lub czasu jej podania zmniejszają odsetek uzyskiwanych odpowiedzi - https://www.researchgate.net/publication/327367007_Zastosowa...

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W 1986 roku Dixon i wsp. przeprowadzili analizę retrospektywną danych ze swojego ośrodka (M.D. Anderson Cancer Center, Houston), aby ocenić wpływ wieku na wyniki leczenia DLBCL według programu CHOP [11]. Stwierdzono, że u pacjentów w wieku powyżej 65 lat, którzy otrzymali leczenie w dawkach należnych, częstość CR była większa, a przeżycie dłuższe bez wzrostu toksyczności leczenia niż u chorych, którzy otrzymali dawki zmniejszone - https://journals.viamedica.pl/oncology_in_clinical_practice/... - page 3 (right column)


11 Dixon D.O., Neilan B., Jones S.E. i wsp. Effect of age on therapeutic outcome in advanced diffused histiocytic lymphoma: the Southwest Oncology Group experience. J. Clin. Oncol. 1986; 4: 295–305 - https://journals.viamedica.pl/oncology_in_clinical_practice/... - page 9

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Treatment guidelines included an initial dose reduction of 50% for patients aged 65 or older and for younger patients with bone marrow compromise. Despite protocol specifications, 23 of 81 patients aged 65 or older received initial full-dose therapy. When these patients were compared with younger patients on whom full-dose chemotherapy was started, survival curves, but not CR rates, were still significantly different. There were no significant differences in duration of CR or frequency of treatment complications. These data suggest that older age is associated with a worse prognosis in advanced DHL. Moreover, the initial dose reduction for patients aged 65 or older may have contributed to their inferior outcomes. - https://www.ncbi.nlm.nih.gov/pubmed/3512783

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The primary objective of the study was dose‐intensity. Dose intensity was 89% and was similar in the two arms. Forty‐one percent of patients received all four full‐dose R‐CHOP‐14 cycles with minimal delays (≤3 d), while significant dose reduction to <80% occurred in 23% of patients. - https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.13358

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Administration of full-dose R-CHOP (rituximab/cyclophosphamide/doxorubicin/vincristine/prednisone) chemotherapy is important to maximize response in patients with intermediate-or high-grade non-Hodgkin lymphoma but might be difficult in older patients. - https://www.ncbi.nlm.nih.gov/pubmed/17562245