Glossary entry (derived from question below)
English term or phrase:
RET
Spanish translation:
RET — REarranged during Transfección > REordenado durante la Transfección
Added to glossary by
Charles Davis
Sep 29, 2018 16:27
5 yrs ago
20 viewers *
English term
RET
English to Spanish
Medical
Medical: Pharmaceuticals
Investigator\'s Brochure (Preclinical pharmacology)
Hola a todos:
Estoy traduciendo el manual de investigador de un fármaco y en esta parte menciona quinasas/cinasas. Algunas están incluidas en la lista de abreviaturas pero no es el caso de RET.
El texto dice lo siguiente:
Preclinical pharmacology
(DRUG) was first discovered as an inhibitor of several protein kinase C (PKC) isoforms. It is now established that (DRUG) and two major circulating metabolites are multi-targeted protein kinase inhibitors with activity against mutant forms of FLT3 and KIT, as well as several kinases involved in their signaling pathways or otherwise implicated in acute myeloid leukemia (AML), such as via stromal support, including AURK, IGF1R, JAK, LYN, PDPK1, PIM1, RET, SYK and VEGFR2. (DRUG) binds to the catalytic domain of these kinases and inhibits the mitogenic signaling of the respective growth factors in cells and results in growth arrest.
Alguna sugerencia?
Desde ya muchas gracias!
Estoy traduciendo el manual de investigador de un fármaco y en esta parte menciona quinasas/cinasas. Algunas están incluidas en la lista de abreviaturas pero no es el caso de RET.
El texto dice lo siguiente:
Preclinical pharmacology
(DRUG) was first discovered as an inhibitor of several protein kinase C (PKC) isoforms. It is now established that (DRUG) and two major circulating metabolites are multi-targeted protein kinase inhibitors with activity against mutant forms of FLT3 and KIT, as well as several kinases involved in their signaling pathways or otherwise implicated in acute myeloid leukemia (AML), such as via stromal support, including AURK, IGF1R, JAK, LYN, PDPK1, PIM1, RET, SYK and VEGFR2. (DRUG) binds to the catalytic domain of these kinases and inhibits the mitogenic signaling of the respective growth factors in cells and results in growth arrest.
Alguna sugerencia?
Desde ya muchas gracias!
Proposed translations
(Spanish)
| 4 +2 | RET — REarranged during Transfección > REordenado durante la Transfección |
Charles Davis
|
References
| Ret |
Chema Nieto Castañón
|
Change log
Oct 13, 2018 04:16: Charles Davis Created KOG entry
Proposed translations
+2
41 mins
Selected
RET — REarranged during Transfección > REordenado durante la Transfección
En español se emplea RET tal cual. Si necesitas saber qué significa la sigla, es esto.
"The RET (REarranged during Transfection) proto-oncogene, situated on chromosome sub-band 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest. RET is a receptor tyrosine kinase involved in cell proliferation, neuronal navigation, cell migration, and cell differentiation."
http://tcr.amegroups.com/article/view/16196/html
"En su estudio, el Dr. Knight y el equipo señalan que un tipo de RTK – re-ordenado durante la transfección (RET) – está regulado positivamente en las células madre formadoras de músculo, o mioblastos, que expresan una proteína llamada DUX4. Esta proteína está codificada por el gen DUX4, situado en la región D4Z4 implicada en la FSHD."
http://fshd-spain.org/2016/12/23/farmaco-contra-el-cancer-pu...
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Note added at 43 mins (2018-09-29 17:10:40 GMT)
--------------------------------------------------
"Identificación de los mecanismos moleculares que median la función de la proteína Gas1 a través del receptor tirosina quinasa Ret"
https://repositorio.uam.es/handle/10486/663518
--------------------------------------------------
Note added at 45 mins (2018-09-29 17:12:23 GMT)
--------------------------------------------------
" Receptor tyrosine kinases:
Receptor tyrosine kinases (RTKs), a family of cell-surface receptors, which transduce signals to polypeptide and protein hormones, cytokines and growth factors are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism, cell migration and cell cycle control [1-2,4]. In the human genome, 58 RTKs have been identified, which fall into 20 families [3]. [...]
Type XIV RTKs: RET"
https://www.genenames.org/cgi-bin/genefamilies/set/321
"The RET (REarranged during Transfection) proto-oncogene, situated on chromosome sub-band 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest. RET is a receptor tyrosine kinase involved in cell proliferation, neuronal navigation, cell migration, and cell differentiation."
http://tcr.amegroups.com/article/view/16196/html
"En su estudio, el Dr. Knight y el equipo señalan que un tipo de RTK – re-ordenado durante la transfección (RET) – está regulado positivamente en las células madre formadoras de músculo, o mioblastos, que expresan una proteína llamada DUX4. Esta proteína está codificada por el gen DUX4, situado en la región D4Z4 implicada en la FSHD."
http://fshd-spain.org/2016/12/23/farmaco-contra-el-cancer-pu...
--------------------------------------------------
Note added at 43 mins (2018-09-29 17:10:40 GMT)
--------------------------------------------------
"Identificación de los mecanismos moleculares que median la función de la proteína Gas1 a través del receptor tirosina quinasa Ret"
https://repositorio.uam.es/handle/10486/663518
--------------------------------------------------
Note added at 45 mins (2018-09-29 17:12:23 GMT)
--------------------------------------------------
" Receptor tyrosine kinases:
Receptor tyrosine kinases (RTKs), a family of cell-surface receptors, which transduce signals to polypeptide and protein hormones, cytokines and growth factors are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism, cell migration and cell cycle control [1-2,4]. In the human genome, 58 RTKs have been identified, which fall into 20 families [3]. [...]
Type XIV RTKs: RET"
https://www.genenames.org/cgi-bin/genefamilies/set/321
4 KudoZ points awarded for this answer.
Comment: "Selected automatically based on peer agreement."
Reference comments
1 hr
Chema Nieto Castañón
Spain
Spain
Native in Spanish
Specializes in field
Spain
Psychologist & Emergency Physician
Native in: Spanish (Variant: Standard-Spain) 
Works in: English to Spanish
Related KudoZ points
:
553
Reference:
Ret
Ret es el Receptor Tirosina Quinasa (RTK) para los factores neurotróficos de la familia de GDNF, que median supervivencia, diferenciación, migración o ...
https://www.google.es/url?sa=t&source=web&rct=j&url=https://...
Análisis de los receptores tirosina quinasa ALK, RET y ROS en los adenocarcinomas nasosinusales
https://www.google.es/url?sa=t&source=web&rct=j&url=http://d...
https://www.google.es/url?sa=t&source=web&rct=j&url=https://...
Análisis de los receptores tirosina quinasa ALK, RET y ROS en los adenocarcinomas nasosinusales
https://www.google.es/url?sa=t&source=web&rct=j&url=http://d...
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