Sep 18, 2016 19:49
7 yrs ago
English term
hydroxylated on the tertiary centre and on one of the methyl groups
English to Russian
Medical
Chemistry; Chem Sci/Eng
Ibuprofen is metabolised in animals and humans by oxidation of the isobutyl group and glucuronidation of the carboxyl moiety.
The isobutyl group is hydroxylated both on the tertiary centre, giving 2-(4-(2hydroxy-2-methylpropyl)phenyl)-propionic acid, and also on one of the methyl groups, giving 2-(4-(2-hydroxymethy1-propyl)phenyl)-propionic acid which is then further oxidized to 2-(4-(carboxypropyl)phenyl)-propionic acid.
The isobutyl group is hydroxylated both on the tertiary centre, giving 2-(4-(2hydroxy-2-methylpropyl)phenyl)-propionic acid, and also on one of the methyl groups, giving 2-(4-(2-hydroxymethy1-propyl)phenyl)-propionic acid which is then further oxidized to 2-(4-(carboxypropyl)phenyl)-propionic acid.
Proposed translations
+1
49 mins
Selected
см.
Гидроксилирование изобутильной группы происходит как по третичному атому углерода, так и по одной из метильных групп...
--------------------------------------------------
Note added at 51 mins (2016-09-18 20:40:54 GMT)
--------------------------------------------------
При нитровании изобутана реакция идет преимущественно по третичному атому углерода, как и в случае бромирования.
http://tinyurl.com/h5jgo5l
--------------------------------------------------
Note added at 51 mins (2016-09-18 20:40:54 GMT)
--------------------------------------------------
При нитровании изобутана реакция идет преимущественно по третичному атому углерода, как и в случае бромирования.
http://tinyurl.com/h5jgo5l
Note from asker:
| <b>mas63</b>, спасибо! |
4 KudoZ points awarded for this answer.
Something went wrong...