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Jan 17, 2015 20:15
9 yrs ago
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English term
interday precision
English to Croatian
Science
Medical (general)
therapeutic drug monitoring
The assay of enantiomers of chiral compounds requires either stereoselective derivatisation of
the drugs prior to their quantification, or their separation by chiral chromatographic GC or HPLC columns. LC-MS/MS may be the method of choice. As an example, the TDM of the enantiomers of methadone using a classical detection method such as fluorescence or ultraviolet light absorption is often jeopardized by comedication or by coconsumption drugs of abuse. These problems may be circumvented by use of a mass detector, preferably a tandem mass spectrometer.
Within the therapeutic reference range, intraday- and interday precision should not exceed 15 % (coefficient of variation) and accuracy should not deviate more than 15 % from the nominal value [114,219].
the drugs prior to their quantification, or their separation by chiral chromatographic GC or HPLC columns. LC-MS/MS may be the method of choice. As an example, the TDM of the enantiomers of methadone using a classical detection method such as fluorescence or ultraviolet light absorption is often jeopardized by comedication or by coconsumption drugs of abuse. These problems may be circumvented by use of a mass detector, preferably a tandem mass spectrometer.
Within the therapeutic reference range, intraday- and interday precision should not exceed 15 % (coefficient of variation) and accuracy should not deviate more than 15 % from the nominal value [114,219].