Phase II study of carboplatin and edatrexate (10-EdAM) with ...
by MH Huber - 1994 - Cited by 3 - Related articles
Edatrexate is a new antifolate with improved preclinical antitumor activity when compared to methotrexate. The purpose of this study was to define the ...
www.ncbi.nlm.nih.gov/pubmed/7775135

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New Antifolates: Pharmacology and Clinical Applications ...
by CH Takimoto - 1996 - Cited by 19 - Related articles
Methotrexate • Trimetrexate • Edatrexate • Piritrexim • ZD1694 • Lometrexol • AG337 • LY231514 • ... Methotrexate differs from the essential vitamin, folic acid, ...... Skin reactions induced by trimetrexate, an analog of methotrexate. ...
theoncologist.alphamedpress.org/cgi/content/full/1/1/68 - Similar

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A Structurally Altered Human Reduced Folate Carrier with Increased ...
by G Jansen - 1998 - Cited by 123 - Related articles
Increased Folic Acid Transport Mediates a Novel Mechanism of. Antifolate Resistance* .... methotrexate; EDX, edatrexate; TMQ, trimetrexate; PT523, Nα-(4- ... analogues such as MTX. In contrast and thus far in the human ...
www.jbc.org/content/273/46/30189.full.pdf

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edatrexate
A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)


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idatrexate

not listed in the above reference