Glossary entry

Spanish term or phrase:

no se acumuló al repetir la dosis

English translation:

did not accumulate after the repeated dose

Added to glossary by Adam Burman
Nov 2, 2006 08:35
17 yrs ago
Spanish term

no se acumuló al repetir la dosis

Spanish to English Medical Medical: Pharmaceuticals Investigator's brochure
This section deals with the "absorption" of desvenlafaxine.

Los valores de AUC en el día 14 y 1 fueron similares, lo que indica que la desvenlafaxina no se acumuló al repetir la dosis.

Discussion

Lia Fail (X) Nov 3, 2006:
Results of single and repeat dose studies of the oral matrix ...
In the repeat dose study, a degree of drug accumulation was noted as steady state was achieved, although comparisons of C max, C min and AUC(0,12 h) after ...
www.blackwell-synergy.com/links/doi/10.1046/j.1365-2125.199... - Similar pages
Lia Fail (X) Nov 3, 2006:
PDF] Acetaminophen accumulation in pediatric patients after repeated ...
File Format: PDF/Adobe Acrobat
acetaminophen may accumulate after repeated therapeutic doses in children with fever. ... differences in total AUC and t,z after the first dose .

Proposed translations

+6
5 mins
Selected

did not accumulate after the repeated dose

Pretty sure it is just this.

For example:

"Accumulation of full-length oligonucleotide after repeat dose administration is consistent with the elimination of half-lives"

from Accumulation of full-length oligonucleotide after repeat dose administration is consistent with the elimination of half-lives estimated in various tissues ...
dmd.aspetjournals.org/cgi/content/full/25/11/1272

or

The absence of accumulation in tissues was confirmed in a 90-day repeated dose study

from:

www.emea.eu.int/pdfs/vet/mrls/007496en.pdf

and many others

Good luck


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Note added at 7 mins (2006-11-02 08:43:20 GMT)
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Or "after repeating the dose"

Sentence would read:

"The AUC values on days 14 and 1 were similar, indicating that desvenlafaxine did not accumulate after repeating the dose"
Peer comment(s):

agree Barbara Thomas
31 mins
Thanks
agree Irina Dicovsky - MD (X)
44 mins
Thanks Irina
agree liz askew : yes, or "after repeating the dose" as you said. I prefer this!
1 hr
Yes, I also prefer "after repeating the dose". Thanks Liz
agree Hebe Martorella
3 hrs
Thanks again Hebe
agree Roxanna Delgado
6 hrs
Thanks once again!
agree Sonia Iujvidin
11 hrs
Thanks here as well Sonia
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Thanks David!"
10 mins

did not get accumulated after the repetition of the dose

I would put it this way.
Something went wrong...
23 mins

did not accumulate/was not accumulative after repeat dose administration

Another way of saying it
Something went wrong...
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