affinity maturation

Slovak translation: afinitná maturácia

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00:54 Oct 28, 2020
English to Slovak translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Slovak translation:afinitná maturácia
Definition:
Proces vytvárania protilátok so zvýšenou väzbovou afinitou sa nazýva afinitná maturácia.
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Alžbeta Takácsová
Slovakia
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4 KudoZ points were awarded for this answer



Summary of translations provided
4 +2afinitná maturácia
Alžbeta Takácsová


  

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11 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
afinitná maturácia


Definition from antibodyresearch.net:
Proces vytvárania protilátok so zvýšenou väzbovou afinitou sa nazýva afinitná maturácia.

Example sentence(s):
  • Aktivované bunky využívajú úžasný mechanizmus, ktorému sa hovorí afinitná maturácia, ktorý bunke umožňuje, aby sa dokonale „prispôsobila“ konečnému tvaru svojej proteínovej protilátky, takže sa stane dokonalým doplnkom invazívneho vírusu osýpok ( Li et al., 2003; Adams et al., 2003). - blog.eugenika.sk  
Alžbeta Takácsová
Slovakia
Local time: 01:13
Native speaker of: Native in SlovakSlovak
PRO pts in category: 64

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Veronika Kvietkova
1 day 6 hrs
  -> Ďakujem

Yes  Beata Fabova
5 days
  -> Ďakujem
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