affinity maturation

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00:54 Oct 28, 2020
English to Croatian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
4 +1afinitetno sazrijevanje
Mirna Vilisic


  

Translations offered


2 days 19 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
afinitetno sazrijevanje


Definition from own experience or research:
Afinitetno sazrijevanje proces je u imunologiji kojim limfociti B prilikom imunosnog odgovora proizvode protutijela s povećanim afinitetom za antigen nakon opetovane izloženosti tom antigenu.

Example sentence(s):
  • Još nije poznato da li je količina TFH limfocita važna za afinitetno sazrijevanje staničnog odgovora B-limfocita ili su za to presudni TFH limfociti s posebnim funkcijama (Streeck i sur. 2013). - PMF, Zagreb  
  • Pomoću citokina i CD-40L liganda potiću proliferaciju, diferencijaciju i aktivnost aktiviranih B-stanica. Ključne su za afinitetno sazrijevanje i prekapčanje izotipa antitijela. - Wikipedia  
Mirna Vilisic
Croatia
Local time: 15:36
Native speaker of: Native in CroatianCroatian
PRO pts in category: 35

Votes in favor of/against selecting this as the best translation of the term asked
Yes  drazenborcic
7 days
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